| Expression pattern: |
UP |
| Associated gene: |
LIPH |
| Associated microRNA: |
miR-195-5p |
| Biological function: |
Promotes PTC cell proliferation, colony formation, migration and invasion; inhibits apoptosis; promotes tumor growth in vivo. |
| Molecular mechanism: |
Acts as a miRNA sponge for miR-195-5p to upregulate LIPH (ceRNA-like regulation). |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); apoptosis (inhibits); EMT (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; RNA-seq; RNase R Treatment; Actinomycin D / DRB Stability Assay; Transfection; Colony Formation Assay; MTT; Western Blot; Annexin V/PI Flow Cytometry; Transwell Assay; Luciferase Reporter Assay; Bioinformatics Analysis; Clinical Sample Validation; In Vivo Animal Model |
| Clinical significance: |
- |
| Description: |
circ_LDLR is upregulated in papillary thyroid carcinoma and functions as an oncogenic circRNA. It promotes malignant phenotypes and tumor growth by sponging miR-195-5p, thereby increasing LIPH expression (circ_LDLR/miR-195-5p/LIPH axis). |
| Confidence score: |
0.7799 |