circRNA basic information
circBase ID: hsa_circ_0000129
Name: -
Synonym: -
Host Gene: -
Genomic location(hg19): chr1:151145974-151149507:-
Genomic location(hg38): chr1:151173498-151177031:-
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0007254
MONDO name: breast cancer
Disease details: breast cancer
Disease DO ID:
 1612
Disease MeSH ID:
 -
Disease NCIt ID:
 C9335
Disease ICD11 ID:
 1047754165
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

breast cancer tissues; adjacent paracancerous tissues
Cell lines:

MCF-7; MDA-MB-231; MDA-MB-468; MCF10A
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: EZH2
Associated microRNA: -
Biological function: promotes proliferation; promotes migration; promotes colony formation
Molecular mechanism: Upregulates and positively regulates EZH2 expression (oncogene) in breast cancer cell lines.
Biological pathway or process:

proliferation (promotes); migration (promotes); ceRNA regulation (other)
Detected method:
Q
Validation methods:

RT-qPCR; Clinical Sample Validation; Transfection; MTT; Colony Formation Assay; Transwell Assay; Western Blot; Bioinformatics Analysis
Clinical significance:

High hsa_circ_0000129 expression was significantly associated with lymph node metastasis and a higher tumor-node-metastasis stage; may represent a prognostic biomarker for breast cancer.
Description:

hsa_circ_0000129 is upregulated in breast cancer tissues and cell lines and promotes malignant phenotypes (proliferation, migration, colony formation). Mechanistically, it positively regulates EZH2 expression in breast cancer cells and is associated with lymph node metastasis and higher TNM stage, suggesting prognostic potential.
Confidence score:

0.5732
Other information
Title:

Upregulated hsa_circ_0000129 expression promotes proliferation and migration of breast cancer cells.

Journal: Oncology letters
Published: 2021
PubMed ID: 33664803
Study type:

combined biological and clinical study
Data availability: GSE111504
Code availability: -