circRNA basic information
circBase ID: hsa_circ_0000384
Name: hsa_circ_MRPS35
Synonym: circMRPS35
Host Gene: MRPS35
Genomic location(hg19): chr12:27867712-27877119:+
Genomic location(hg38): chr12:27714779-27724186:+
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0001056
MONDO name: gastric cancer
Disease details: gastric cancer / GC
Disease DO ID:
 10534
Disease MeSH ID:
 -
Disease NCIt ID:
 C9331
Disease ICD11 ID:
 1397617262
Disease OMIM ID:
 613659
Species: Human
Species details: Homo sapiens
Tissue specimen:

cancerous gastric tissues; adjacent tumor-free gastric tissues
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: TFDP1, KRAS, MET, MYBL2, LMNB1, CBFB, CDC7, E2F5, HMGA1, HMGA2, CBX3, IGF2BP3, KIF11, PDGFB, SMC1A, CDC25A
Associated microRNA: has-miR-326, has-miR-23b-3p, has-miR-30a-5p, has-miR-30c-5p, has-let-7c-5p
Biological function: accelerates GC cell proliferation and invasion
Molecular mechanism: ceRNA mechanism by sponging miRNAs to posttranscriptionally regulate hub gene expression (e.g., TFDP1, KRAS, MET, LMNB1)
Biological pathway or process:

proliferation (promotes); invasion (promotes); ceRNA regulation (promotes)
Detected method:
Q
M
Validation methods:

Microarray; RT-qPCR; Clinical Sample Validation; Bioinformatics Analysis
Clinical significance:

might be served as promising biomarkers for GC diagnosis and targeted therapy
Description:

hsa_circ_0000384 (circMRPS35) is up-regulated in gastric cancer tissues and is proposed to promote GC progression by acting as a ceRNA that sponges multiple miRNAs (e.g., has-miR-30a-5p/has-miR-30c-5p, has-miR-326), thereby increasing expression of hub oncogenic genes such as TFDP1, KRAS, MET and LMNB1.
Confidence score:

0.4032
Other information
Title:

Identification of Novel circRNA-Based ceRNA Network Involved in the Pathogenesis of Gastric Cancer.

Journal: International journal of genomics
Published: 2022
PubMed ID: 35685832
Study type:

combined biological and clinical study
Data availability: GSE152309; GSE121445; TCGA-STAD
Code availability: -