| Expression pattern: |
UP |
| Associated gene: |
FZD7, Ago2 |
| Associated microRNA: |
miR-944 |
| Biological function: |
promotes doxorubicin resistance and tumor progression (proliferation, migration, invasion) and inhibits apoptosis in DOX-resistant CRC; circCSPP1 knockdown enhances DOX sensitivity and suppresses tumor growth in vivo |
| Molecular mechanism: |
ceRNA/miRNA sponge mechanism: circCSPP1 targets miR-944 and regulates FZD7 via miR-944/FZD7 axis |
| Biological pathway or process: |
drug resistance (promotes); proliferation (promotes); migration (promotes); invasion (promotes); apoptosis (inhibits); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); RNA Pull-Down; Transfection; MTT; Transwell Assay; Annexin V/PI Flow Cytometry; Western Blot; In Vivo Animal Model |
| Clinical significance: |
- |
| Description: |
circCSPP1 is up-regulated in DOX-resistant colorectal cancer tissues and cell models. Silencing circCSPP1 increases doxorubicin sensitivity and suppresses malignant phenotypes (proliferation, migration, invasion) while promoting apoptosis, partly through a ceRNA mechanism involving miR-944 and downstream target FZD7, and it inhibits xenograft tumor growth in vivo. |
| Confidence score: |
0.7087 |