circRNA basic information
circBase ID: hsa_circ_0000005
Name: hsa_circ_CDK11A
Synonym: -
Host Gene: CDK11A
Genomic location(hg19): chr1:1586822-1650894:-
Genomic location(hg38): chr1:1655368-1719455:-
Subcellular localization: nucleus
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005580
MONDO name: esophageal squamous cell carcinoma
Disease details: esophageal squamous cell carcinoma
Disease DO ID:
 3748
Disease MeSH ID:
 C562729; D000077277
Disease NCIt ID:
 C4024
Disease ICD11 ID:
 1417891145
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

ESCC tumor tissues; paired non-tumor tissues
Cell lines:

KYSE270; KYSE520; KYSE410
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UN
Associated gene: -
Associated microRNA: -
Biological function: Prognostic signature component for overall survival prediction in ESCC (high expression associated with poor prognosis).
Molecular mechanism: Not specified (functional prediction via co-expression/GO/KEGG only).
Biological pathway or process:

angiogenesis (other); migration (other); other pathway/process (other)
Detected method:
Q
S
Validation methods:

RNA-seq; RNase R Treatment; RT-qPCR; Back-Splice Junction PCR / divergent primers PCR; Sanger Sequencing; FISH / smFISH; Clinical Sample Validation; Survival Analysis; ROC Analysis; Bioinformatics Analysis
Clinical significance:

Part of a four-circRNA prognostic signature that stratifies ESCC patients into high- and low-risk groups with significantly different overall survival; high expression is associated with poor prognosis.
Description:

hsa_circ_0000005 (CDK11A-derived) is a component of the four-circRNA prognostic signature for ESCC overall survival. It is annotated as high expression with poor prognosis and contributes positively to the model risk score.
Confidence score:

0.7277
Other information
Title:

RNA sequencing reveals the expression profiles of circRNA and identifies a four-circRNA signature acts as a prognostic marker in esophageal squamous cell carcinoma.

Journal: Cancer cell international
Published: 2021
PubMed ID: 33663506
Study type:

combined biological and clinical study
Data availability: -
Code availability: -