circRNA basic information
circBase ID: -
Name: -
Synonym: circHIPK3
Host Gene: HIPK3
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: cytoplasm
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005311
MONDO name: atherosclerosis
Disease details: atherosclerosis
Disease DO ID:
 1936
Disease MeSH ID:
 D050197
Disease NCIt ID:
 C35768
Disease ICD11 ID:
 109367356
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

-
Cell lines:

HASMC; HUASMC
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: CDK6
Associated microRNA: miR-637
Biological function: promotes VSMC proliferation and cell cycle progression; inhibits apoptosis
Molecular mechanism: circHIPK3 acts as a miR-637 sponge to regulate CDK6 expression
Biological pathway or process:

proliferation (promotes); apoptosis (inhibits); cell cycle (promotes); ceRNA regulation (other)
Detected method:
Q
Validation methods:

RT-qPCR; RNase R Treatment; Nuclear-Cytoplasmic Fractionation; Luciferase Reporter Assay; Transfection; CCK8; Annexin V/PI Flow Cytometry; Bioinformatics Analysis
Clinical significance:

-
Description:

In human VSMCs relevant to atherosclerosis, circHIPK3 is up-regulated and mainly localized in the cytoplasm. circHIPK3 functions as a ceRNA to sponge miR-637, thereby relieving repression of CDK6 and promoting VSMC proliferation/cell-cycle progression while inhibiting apoptosis.
Confidence score:

0.6579
Other information
Title:

Identification of Differently Expressed mRNAs in Atherosclerosis Reveals CDK6 Is Regulated by circHIPK3/miR-637 Axis and Promotes Cell Growth in Human Vascular Smooth Muscle Cells.

Journal: Frontiers in genetics
Published: 2021
PubMed ID: 33659023
Study type:

biological research
Data availability: GSE6088
Code availability: -