| Expression pattern: |
UP |
| Associated gene: |
HMGA2, Ago2 |
| Associated microRNA: |
miR-204-3p |
| Biological function: |
Promotes OS cell proliferation, migration and invasion, and inhibits apoptosis. |
| Molecular mechanism: |
Acts as a miRNA sponge binding miR-204-3p, thereby regulating HMGA2 expression. |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); apoptosis (inhibits); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; RNase R Treatment; RIP (RNA Immunoprecipitation); Luciferase Reporter Assay; Transfection; CCK8; Transwell Assay; Annexin V/PI Flow Cytometry; Western Blot; Clinical Sample Validation; Survival Analysis; ROC Analysis; Bioinformatics Analysis |
| Clinical significance: |
High circUBAP2 expression levels in patients with OS were associated with a lower survival rate; circUBAP2 effectively distinguished OS tissues from paired non-cancerous tissues (AUC =0.7664). |
| Description: |
circUBAP2 is up-regulated in osteosarcoma and functions as an oncogenic circRNA. It promotes proliferation, migration and invasion while inhibiting apoptosis, mainly by sponging miR-204-3p to derepress HMGA2 (circUBAP2/miR-204-3p/HMGA2 axis). High circUBAP2 expression is associated with worse overall survival and has diagnostic potential by ROC analysis. |
| Confidence score: |
0.819 |