| Expression pattern: |
UP |
| Associated gene: |
FGF-2, MEK/ERK signaling pathway |
| Associated microRNA: |
miR-641 |
| Biological function: |
Promotes osteoarthritis progression by promoting extracellular matrix catabolism and inflammation (increases MMP13 and IL-6, decreases Col II). |
| Molecular mechanism: |
Acts as a miRNA sponge (ceRNA-like) for miR-641, thereby regulating FGF-2 and activating MEK/ERK signaling to modulate ECM metabolism and inflammation. |
| Biological pathway or process: |
ERK (promotes); inflammation (promotes); other pathway/process (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Transfection; RNA Pull-Down; Luciferase Reporter Assay; Western Blot; IF (Immunofluorescence); Bioinformatics Analysis |
| Clinical significance: |
Could be utilized as a biomarker and target for OA therapy. |
| Description: |
circRNA-CDR1as is up-regulated in OA chondrocytes and promotes OA progression. It sponges miR-641, derepressing FGF-2 and activating MEK/ERK signaling, which increases MMP13 and IL-6 and reduces type II collagen, thereby enhancing ECM catabolism and inflammation. |
| Confidence score: |
0.6903 |