| Expression pattern: |
UP |
| Associated gene: |
KIF3A, E-cadherin, N-cadherin, vimentin, snail |
| Associated microRNA: |
- |
| Biological function: |
Promotes CRC cell proliferation, colony formation, migration and invasion; inhibits apoptosis; promotes EMT. |
| Molecular mechanism: |
Activates the KIF3A-mediated EMT signaling pathway (regulates KIF3A and EMT markers). |
| Biological pathway or process: |
EMT (promotes); migration (promotes); invasion (promotes); proliferation (promotes); apoptosis (inhibits) |
| Detected method: |
Q
M
|
| Validation methods: |
Microarray; Bioinformatics Analysis; RT-qPCR; Clinical Sample Validation; Transfection; MTT; Colony Formation Assay; Annexin V/PI Flow Cytometry; Cell Cycle Assay; Transwell Assay; Western Blot; Survival Analysis |
| Clinical significance: |
Higher expression levels of circRNA_101951 were associated with a lower survival rate in patients with CRC; proposed as a potential biomarker. |
| Description: |
circRNA_101951 is upregulated in colorectal cancer tissues and CRC cell lines and is associated with worse patient survival. Knockdown suppresses proliferation, colony formation, migration and invasion while increasing apoptosis and inducing G1 arrest, partly by inhibiting the KIF3A-mediated EMT program. |
| Confidence score: |
0.6778 |