circRNA basic information
circBase ID: hsa_circ_0007534
Name: -
Synonym: -
Host Gene: -
Genomic location(hg19): chr17:61869771-61877977:+
Genomic location(hg38): chr17:63792411-63800617:+
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0007254
MONDO name: breast cancer
Disease details: breast cancer
Disease DO ID:
 1612
Disease MeSH ID:
 -
Disease NCIt ID:
 C9335
Disease ICD11 ID:
 1047754165
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

breast cancer tissues; corresponding adjacent non-cancerous tissues
Cell lines:

MCF-7; HS-578T; T47D; BT549; MDA-MB-231; SKBR-3
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: RFC3
Associated microRNA: miR-26a, miR-26b, miR-200b, miR-200c, miR-429
Biological function: unknown
Molecular mechanism: Co-expression network suggests indirect regulation of RFC3 via miRNAs (miR-26a/26b/200b/200c/429); miRNA binding not experimentally verified.
Biological pathway or process:

ceRNA regulation (other)
Detected method:
Q
S
Validation methods:

RNA-seq; RT-qPCR; Back-Splice Junction PCR / divergent primers PCR; Sanger Sequencing; Clinical Sample Validation; Bioinformatics Analysis
Clinical significance:

-
Description:

hsa_circ_0007534 is up-regulated in breast cancer tissues and is included in a predicted circRNA-miRNA-mRNA network potentially regulating RFC3 through several miRNAs, but no direct functional assays for this circRNA were reported.
Confidence score:

0.585
Other information
Title:

Downregulation of hsa_circ_0011946 suppresses the migration and invasion of the breast cancer cell line MCF-7 by targeting RFC3.

Journal: Cancer management and research
Published: 2018
PubMed ID: 29593432
Study type:

combined biological and clinical study
Data availability: -
Code availability: -