| Expression pattern: |
DN |
| Associated gene: |
oxidored-nitro domain-containing protein 1 (NOR1) |
| Associated microRNA: |
miR-103 |
| Biological function: |
Sensitizes HCC cells to cisplatin; inhibits proliferation/cell growth; induces apoptosis; suppresses tumor growth in vivo. |
| Molecular mechanism: |
Acts as a miRNA sponge (ceRNA-like) for miR-103, resulting in increased NOR1 expression and enhanced cisplatin sensitivity. |
| Biological pathway or process: |
proliferation (inhibits); apoptosis (promotes); chemoresistance (inhibits); ceRNA regulation (other) |
| Detected method: |
Q
M
|
| Validation methods: |
Microarray; RT-qPCR; Clinical Sample Validation; Survival Analysis; Transfection; BrdU; Annexin V/PI Flow Cytometry; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); In Vivo Animal Model; IHC (Immunohistochemistry) |
| Clinical significance: |
Low circRNA_101505 level is associated with shorter overall survival in HCC patients. |
| Description: |
circRNA_101505 is down-regulated in HCC, especially in cisplatin-resistant tissues/cell lines, and low expression correlates with worse overall survival. Functionally, circRNA_101505 suppresses proliferation, promotes apoptosis, and increases cisplatin sensitivity by sponging miR-103 to upregulate NOR1. |
| Confidence score: |
0.7789 |