circRNA basic information
circBase ID: hsa_circ_0008301
Name: hsa_circ_TOLLIP
Synonym: hsa_-circ_0008301
Host Gene: TOLLIP
Genomic location(hg19): chr11:1307231-1317024:-
Genomic location(hg38): chr11:1286001-1295794:-
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0010030
MONDO name: Sjogren syndrome
Disease details: primary Sjögren's syndrome
Disease DO ID:
 12894
Disease MeSH ID:
 D012859
Disease NCIt ID:
 C26883
Disease ICD11 ID:
 899463360
Disease OMIM ID:
 270150
Species: Human
Species details: Homo sapiens
Tissue specimen:

peripheral blood
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: TOLLIP, TLR2/4, IL-1beta, IRak1, NF-kappaB, MyD88, TLR-NF-kappaB pathway
Associated microRNA: -
Biological function: hsa_circ_0008301 is increased in peripheral blood of pSS patients, correlates with clinical features and disease activity, decreases after treatment, and may serve as a diagnostic, disease activity, prognosis-related, and potential therapeutic biomarker for pSS.
Molecular mechanism: The study hypothesizes that hsa_circ_0008301 may be involved in pSS inflammation through the MyD88-dependent TLR-NF-kappaB pathway and may be related to TOLLIP gene expression, but no direct mechanistic experiment was performed.
Biological pathway or process:

immune regulation (other); inflammation (other); NF-kappaB (other); other pathway/process (other)
Detected method:
Q
Validation methods:

RT-qPCR; Clinical Sample Validation; ROC Analysis
Clinical significance:

hsa_circ_0008301 has diagnostic value for pSS, can help judge disease activity, is associated with clinical characteristics including disease duration, fatigue, thrombocytopenia, ESR, IgG, complement C3 and ESSDAI, decreases after treatment, and may have significance for prognosis and as a potential therapeutic target.
Description:

This study found that hsa_circ_0008301 is up-regulated in peripheral blood from patients with pSS and is higher in patients with active disease. Its expression correlates with several clinical and laboratory indicators and decreases after treatment, supporting its potential use as a biomarker for pSS diagnosis, disease activity evaluation, and treatment response monitoring. The proposed mechanism is speculative and involves possible participation in pSS inflammation through the MyD88-dependent TLR-NF-kappaB pathway.
Confidence score:

0.4187
Other information
Title:

Hsa_circ_0008301 as a potential biomarker of disease activity for primary Sjogren's syndrome: Increased expression in peripheral blood of patients with primary Sjogren's syndrome.

Journal: International immunopharmacology
Published: 2022
PubMed ID: 36113315
Study type:

clinical study
Data availability: -
Code availability: -