| Expression pattern: |
UP |
| Associated gene: |
CK-MB |
| Associated microRNA: |
- |
| Biological function: |
Auxiliary diagnostic biomarker for IHD-related SCD; associated with myocardial infarction formation and myocardial ischemic damage severity. |
| Molecular mechanism: |
Correlation with CK-MB levels in pericardial fluid (biomarker association). |
| Biological pathway or process: |
not specified |
| Detected method: |
Q
|
| Validation methods: |
RNase R Treatment; divergent primers PCR; Sanger Sequencing; RT-qPCR; Clinical Sample Validation; ROC Analysis; Bioinformatics Analysis; Cohort Study |
| Clinical significance: |
circSLC8A1 showed high sensitivity and specificity for myocardial infarction postmortem; positively correlated with CK-MB in pericardial fluid; used to discriminate IHD-related SCDs (especially MI cases). |
| Description: |
circSLC8A1 is up-regulated in acute ischemic damage and is elevated in myocardium from MI-related IHD SCD autopsy cases. It shows diagnostic utility (ROC performance) for postmortem MI and correlates positively with CK-MB levels in pericardial fluid. |
| Confidence score: |
0.6888 |