| Expression pattern: |
UP |
| Associated gene: |
YAP1, TEAD1, Ago2 |
| Associated microRNA: |
miR-1283 |
| Biological function: |
promotes HCC progression and cell proliferation; inhibits apoptosis; promotes tumor growth in vivo |
| Molecular mechanism: |
Acts as a miR-1283 sponge to increase YAP1/TEAD1 expression and activate YAP1/TEAD1 (Hippo-related) signaling |
| Biological pathway or process: |
Hippo/YAP (promotes); proliferation (promotes); apoptosis (inhibits); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
divergent primers PCR; RT-qPCR; Clinical Sample Validation; Survival Analysis; Transfection; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); Western Blot; CCK8; BrdU; Colony Formation Assay; Annexin V/PI Flow Cytometry; In Vivo Animal Model; IHC (Immunohistochemistry) |
| Clinical significance: |
High circGprc5a expression is associated with reduced overall survival and correlates with tumor size and differentiation stage in HCC patients |
| Description: |
circGprc5a is up-regulated in HCC tissues/cell lines and its high level is associated with poorer overall survival. Functionally, circGprc5a promotes HCC cell proliferation and tumor growth while inhibiting apoptosis by sponging miR-1283 and thereby increasing YAP1/TEAD1 expression/activity. |
| Confidence score: |
0.8067 |