circRNA basic information
circBase ID: -
Name: hsa_circ_ORC2
Synonym: circORC2
Host Gene: ORC2
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0002203
MONDO name: constipation disorder
Disease details: slow transit constipation
Disease DO ID:
 -
Disease MeSH ID:
 D003248
Disease NCIt ID:
 C37930
Disease ICD11 ID:
 502284069
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

peripheral blood
Cell lines:

SMCs; VSMCs
In vivo animal model:

-
circRNA-disease information
Expression pattern:
DN
Associated gene: NST, MLN
Associated microRNA: miR-19a
Biological function: Overexpression of circORC2 exerts a beneficial effect in STC by up-regulating neurotensin and motilin via suppressing miR-19a.
Molecular mechanism: circORC2 sponges miR-19a; miR-19a targets MLN and NST mRNAs; circORC2 up-regulates MLN and NST by down-regulating miR-19a.
Biological pathway or process:

ceRNA regulation (promotes)
Detected method:
Q
Validation methods:

RT-qPCR; Clinical Sample Validation; Bioinformatics Analysis; Luciferase Reporter Assay; Transfection; Western Blot
Clinical significance:

circORC2 level was lowest in the STC group (vs HC/NTC), suggesting association with STC status; overexpression could be beneficial for STC treatment.
Description:

In STC patients, circORC2 is down-regulated in peripheral blood. circORC2 acts as a miR-19a sponge, relieving miR-19a-mediated repression of MLN and NST, thereby increasing motilin and neurotensin signaling that may benefit STC.
Confidence score:

0.6102
Other information
Title:

CircORC2 is involved in the pathogenesis of slow transit constipation via modulating the signalling of miR-19a and neurotensin/motilin.

Journal: Journal of cellular and molecular medicine
Published: 2021
PubMed ID: 33629528
Study type:

combined biological and clinical study
Data availability: The data that support the findings of this study are available from the corresponding author upon reasonable request.
Code availability: -