circRNA basic information
circBase ID: hsa_circ_0005941
Name: hsa_circ_FTO
Synonym: -
Host Gene: FTO
Genomic location(hg19): chr16:53907697-53922863:+
Genomic location(hg38): chr16:53873785-53888951:+
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005233
MONDO name: non-small cell lung carcinoma
Disease details: non-small-cell lung carcinoma
Disease DO ID:
 3908
Disease MeSH ID:
 D002289
Disease NCIt ID:
 C2926
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

-
Cell lines:

A549; A549/DDP
In vivo animal model:

-
circRNA-disease information
Expression pattern:
DN
Associated gene: -
Associated microRNA: -
Biological function: The article suggests that hsa_circ_0005941 derived from FTO may play an important role in A549/DDP resistance to cisplatin, but no direct functional assays were reported for this circRNA.
Molecular mechanism: -
Biological pathway or process:

chemoresistance (other)
Detected method:
Q
S
Validation methods:

RT-qPCR; RNA-seq
Clinical significance:

-
Description:

hsa_circ_0005941 was identified by sequencing and validated by qRT-PCR as suppressed in Cisplatin-resistant A549/DDP cells compared with A549 cells. The authors noted that it is derived from FTO and speculated it may be involved in A549/DDP resistance to cisplatin, but no direct functional mechanism was tested.
Confidence score:

0.1904
Other information
Title:

Circular RNA hsa_circ_0096157 contributes to cisplatin resistance by proliferation, cell cycle progression, and suppressing apoptosis of non-small-cell lung carcinoma cells.

Journal: Molecular and cellular biochemistry
Published: 2020
PubMed ID: 32767026
Study type:

biological research
Data availability: Supplemental Table 1
Code availability: -