| Expression pattern: |
DN |
| Associated gene: |
- |
| Associated microRNA: |
miR-28 |
| Biological function: |
Suppresses NSCLC cell proliferation and promotes apoptosis (tumor suppressor role). |
| Molecular mechanism: |
Acts as a miRNA sponge by directly interacting with oncogenic miR-28 and suppressing miR-28 effects on proliferation and apoptosis. |
| Biological pathway or process: |
proliferation (inhibits); apoptosis (promotes); ceRNA regulation (other) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Nuclear-Cytoplasmic Fractionation; RNA Pull-Down; Transfection; BrdU; Annexin V/PI Flow Cytometry; Clinical Sample Validation; Cohort Study; Survival Analysis; Bioinformatics Analysis |
| Clinical significance: |
Low expression levels of circ-MYBL2 were closely correlated with the poor survival of NSCLC patients. |
| Description: |
In NSCLC, circ-MYBL2 is downregulated and mainly localized in the cytoplasm. It directly binds (sponges) miR-28, thereby antagonizing miR-28’s pro-proliferative and anti-apoptotic effects, consistent with a tumor-suppressive role and association of low circ-MYBL2 with poorer survival. |
| Confidence score: |
0.7513 |