| Expression pattern: |
UP |
| Associated gene: |
AP-1, IRF-4, CDX-2, Zic-1 |
| Associated microRNA: |
miR-1273a |
| Biological function: |
promotes cell viability/proliferation, invasion, and migration; inhibits cell death (apoptosis) in colon cancer cells |
| Molecular mechanism: |
circPIP5K1A inhibits miR-1273a (sponge/antagonistic interaction) and thereby modulates AP-1, IRF-4, CDX-2 and Zic-1 expression |
| Biological pathway or process: |
apoptosis (inhibits); proliferation (promotes); migration (promotes); invasion (promotes); ceRNA regulation (other) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; RNase R Treatment; Clinical Sample Validation; Transfection; Hoechst staining assay; Transwell Assay; Western Blot; Bioinformatics Analysis |
| Clinical significance: |
- |
| Description: |
circPIP5K1A (hsa_circ_0014130, host gene PIP5K1A) is up-regulated in colon cancer tissues and cancer cell lines. Functionally, it promotes cell viability and enhances invasion/migration while its knockdown increases cell death. Mechanistically, it antagonizes miR-1273a and is linked to regulation of AP-1, IRF-4, CDX-2 and Zic-1 expression. |
| Confidence score: |
0.6479 |