| Expression pattern: |
DN |
| Associated gene: |
ROCK2, AGO2 |
| Associated microRNA: |
miR-142-3p |
| Biological function: |
inhibits proliferation; inhibits migration; inhibits invasion; inhibits tumorigenicity; increases cisplatin sensitivity; inhibits autophagy |
| Molecular mechanism: |
circCUL2 acts as a miRNA sponge (ceRNA) for miR-142-3p to regulate ROCK2, thereby modulating autophagy activation and cisplatin resistance. |
| Biological pathway or process: |
ceRNA regulation (promotes); proliferation (inhibits); migration (inhibits); invasion (inhibits); autophagy (inhibits); drug resistance (inhibits) |
| Detected method: |
Q
M
|
| Validation methods: |
Microarray; RT-qPCR; Back-Splice Junction PCR / divergent primers PCR; RNase R Treatment; Sanger Sequencing; Actinomycin D / DRB Stability Assay; Nuclear-Cytoplasmic Fractionation; FISH / smFISH; Clinical Sample Validation; ROC Analysis; Survival Analysis; Bioinformatics Analysis; Luciferase Reporter Assay; RNA Pull-Down; RIP (RNA Immunoprecipitation); Transfection; CCK8; EdU Staining; Colony Formation Assay; Transwell Assay; Wound Healing Assay; Western Blot; IF (Immunofluorescence); MTT; Annexin V/PI Flow Cytometry; TUNEL; In Vivo Animal Model; IHC (Immunohistochemistry) |
| Clinical significance: |
Kaplan-Meier analysis revealed that GC patients with low circCUL2 levels had poor overall survival; ROC analysis showed AUC 0.790 for diagnostic value; serum circCUL2 was decreased in GC patients. |
| Description: |
circCUL2 is down-regulated in gastric cancer tissues, serum, and cell lines and acts as a tumor suppressor. It sponges miR-142-3p to upregulate ROCK2, thereby inhibiting malignant behaviors and autophagy, and increasing cisplatin sensitivity (reducing cisplatin resistance) in GC. |
| Confidence score: |
0.8981 |