circRNA basic information
circBase ID: hsa_circ_0135895
Name: hsa_circ_PTK2
Synonym: -
Host Gene: PTK2
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005291
MONDO name: brain aneurysm
Disease details: primary multiple intracranial aneurysm
Disease DO ID:
 10941
Disease MeSH ID:
 D002532
Disease NCIt ID:
 -
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

peripheral blood mononuclear cells
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: PTK2
Associated microRNA: hsa-miR-619-3p, hsa-miR-4324, hsa-miR-5687, hsa-miR-3529-5p, hsa-miR-379-5p, hsa-miR-4778-3p, hsa-miR-543
Biological function: Predicted to be involved in MIA pathogenesis by regulating leukocyte transendothelial migration via a ceRNA network.
Molecular mechanism: ceRNA mechanism (miRNA sponge) regulating PTK2
Biological pathway or process:

inflammation (other); ceRNA regulation (promotes); other pathway/process (other)
Detected method:
Q
S
Validation methods:

RNA-seq; RNase R Treatment; RT-qPCR; Bioinformatics Analysis; Clinical Sample Validation
Clinical significance:

-
Description:

hsa_circ_0135895 is up-regulated in PBMCs from patients with primary multiple intracranial aneurysm and was RT-qPCR-validated. The study predicts it participates in MIA pathogenesis via a ceRNA mechanism, sponging miRNAs to regulate PTK2 in the leukocyte transendothelial migration-related network.
Confidence score:

0.5135
Other information
Title:

Circular RNA expression profile in human primary multiple intracranial aneurysm.

Journal: Experimental and therapeutic medicine
Published: 2021
PubMed ID: 33603847
Study type:

combined biological and clinical study
Data availability: GSE159631
Code availability: -