| Expression pattern: |
DN |
| Associated gene: |
PDGFB, TNFRSF19, CCND2, CTF1, IL11RA, IL7R, MAOA |
| Associated microRNA: |
hsa-miR-3127-5p, hsa-miR-1306-5p |
| Biological function: |
May act as a tumor suppressor and is associated with cell proliferation-related processes in LUAD. |
| Molecular mechanism: |
ceRNA mechanism via sponging miRNAs to regulate downstream mRNAs in a circRNA-miRNA-mRNA network (ENCORI-based). |
| Biological pathway or process: |
proliferation (other); JAK/STAT (other); ceRNA regulation (other) |
| Detected method: |
M
|
| Validation methods: |
Microarray; Bioinformatics Analysis; Survival Analysis |
| Clinical significance: |
Low hsa_circ_0049271 expression in LUAD; decreased expression was associated with short OS period. |
| Description: |
This study constructed an ENCORI-based ceRNA network in LUAD centered on the down-regulated circRNA hsa_circ_0049271, linking it to hsa-miR-3127-5p/hsa-miR-1306-5p and seven target mRNAs. Genes in this network were enriched in proliferation-related processes and the JAK-STAT pathway, and reduced hsa_circ_0049271 expression was associated with shorter overall survival. |
| Confidence score: |
0.348 |