| Expression pattern: |
UP |
| Associated gene: |
E2F3 |
| Associated microRNA: |
miR-432-5p |
| Biological function: |
Promotes migration, invasion and proliferation; promotes tumor growth in vivo; inhibits apoptosis. |
| Molecular mechanism: |
Acts as a miRNA sponge for miR-432-5p to regulate E2F3 expression. |
| Biological pathway or process: |
ceRNA regulation (promotes); proliferation (promotes); migration (promotes); invasion (promotes); apoptosis (inhibits) |
| Detected method: |
Q
M
|
| Validation methods: |
Microarray; RT-qPCR; Clinical Sample Validation; Transfection; Transwell Assay; Colony Formation Assay; CCK8; Annexin V/PI Flow Cytometry; Luciferase Reporter Assay; Western Blot; In Vivo Animal Model; Bioinformatics Analysis |
| Clinical significance: |
might be a novel diagnostic target for PC |
| Description: |
circCDR1as is up-regulated in pancreatic cancer tissues and cell lines and promotes malignant phenotypes. Mechanistically, it sponges miR-432-5p, thereby increasing E2F3 expression and enhancing proliferation, migration/invasion, and xenograft tumor growth while reducing apoptosis. |
| Confidence score: |
0.6835 |