| Expression pattern: |
UP |
| Associated gene: |
GOT1 |
| Associated microRNA: |
miR-377-3p |
| Biological function: |
promotes cisplatin-resistance, promotes proliferation and viability under cisplatin treatment, inhibits apoptosis; knock-down increases cisplatin-sensitivity |
| Molecular mechanism: |
Acts as a ceRNA to sponge miR-377-3p, thereby upregulating GOT1 (via binding to GOT1 3'UTR). |
| Biological pathway or process: |
ceRNA regulation (promotes); proliferation (promotes); apoptosis (inhibits); drug resistance (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RNase R Treatment; RT-qPCR; Bioinformatics Analysis; Luciferase Reporter Assay; RNA Pull-Down; Transfection; CCK8; Annexin V/PI Flow Cytometry; Western Blot; In Vivo Animal Model; IHC (Immunohistochemistry) |
| Clinical significance: |
Targeting the hsa_circRNA_103809/miR-377-3p/GOT1 pathway may improve the therapeutic efficacy of cisplatin for NSCLC treatment in clinic. |
| Description: |
hsa_circRNA_103809 is up-regulated in cisplatin-resistant NSCLC cells and promotes cisplatin resistance. It functions as a ceRNA by sponging miR-377-3p to increase GOT1, thereby maintaining proliferation/viability and suppressing apoptosis under cisplatin; silencing it sensitizes resistant cells and inhibits xenograft growth with cisplatin. |
| Confidence score: |
0.7581 |