| Expression pattern: |
DN |
| Associated gene: |
SND1, YWHAB |
| Associated microRNA: |
- |
| Biological function: |
Inhibits proliferation and invasion, promotes apoptosis, and suppresses tumor metastasis in cervical cancer. |
| Molecular mechanism: |
circ SMARCA5 binds the RBP SND1 and inhibits SND1 binding to YWHAB, thereby downregulating YWHAB. |
| Biological pathway or process: |
proliferation (inhibits); invasion (inhibits); apoptosis (promotes); metastasis (inhibits); other pathway/process (other) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Transfection; CCK8; Transwell Assay; Annexin V/PI Flow Cytometry; Western Blot; RNA Pull-Down; Co-IP; In Vivo Animal Model; Bioinformatics Analysis |
| Clinical significance: |
- |
| Description: |
circ SMARCA5 is down-regulated in cervical cancer tissues/cell lines. Its overexpression suppresses proliferation, invasion, and in vivo tumor growth/metastasis while promoting apoptosis, mechanistically by binding the RBP SND1 and reducing SND1-mediated YWHAB upregulation. |
| Confidence score: |
0.7045 |