circRNA basic information
circBase ID: hsa_circ_0000690
Name: hsa_circ_ITGAL
Synonym: -
Host Gene: -
Genomic location(hg19): chr16:30495147-30495584:+
Genomic location(hg38): chr16:30483826-30484263:+
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005291
MONDO name: brain aneurysm
Disease details: primary multiple intracranial aneurysm
Disease DO ID:
 10941
Disease MeSH ID:
 D002532
Disease NCIt ID:
 -
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

peripheral blood mononuclear cells
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
DN
Associated gene: ITGAL
Associated microRNA: hsa-miR-4726-3p, hsa-miR-4520-3p, hsa-miR-4514, hsa-miR-4692, hsa-miR-6842-3p, hsa-miR-4778-3p
Biological function: Predicted to be involved in MIA pathogenesis by regulating leukocyte transendothelial migration via a ceRNA network; transcriptional regulation of CD11a (ITGAL).
Molecular mechanism: ceRNA mechanism (miRNA sponge) regulating ITGAL
Biological pathway or process:

inflammation (other); ceRNA regulation (promotes); other pathway/process (other)
Detected method:
Q
S
Validation methods:

RNA-seq; RNase R Treatment; RT-qPCR; Bioinformatics Analysis; Clinical Sample Validation
Clinical significance:

-
Description:

hsa_circ_0000690 is down-regulated in PBMCs from patients with primary multiple intracranial aneurysm and was RT-qPCR-validated as significantly different between cases and controls. The study predicts it affects leukocyte transendothelial migration via a ceRNA network, acting as a miRNA sponge to regulate ITGAL (CD11a).
Confidence score:

0.5135
Other information
Title:

Circular RNA expression profile in human primary multiple intracranial aneurysm.

Journal: Experimental and therapeutic medicine
Published: 2021
PubMed ID: 33603847
Study type:

combined biological and clinical study
Data availability: GSE159631
Code availability: -