| Expression pattern: |
DN |
| Associated gene: |
RUNX1 |
| Associated microRNA: |
miR-21-5p |
| Biological function: |
Circ_0027599 acts as a tumour suppressor in gastric cancer, inhibiting GC cell viability, colony formation, migration, invasion, cell cycle progression and in vivo tumour growth. |
| Molecular mechanism: |
Circ_0027599 functions as a miR-21-5p sponge to positively regulate RUNX1 expression, thereby repressing gastric cancer progression. |
| Biological pathway or process: |
proliferation (inhibits); migration (inhibits); invasion (inhibits); metastasis (inhibits); cell cycle (inhibits); EMT (inhibits); ceRNA regulation (other) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Transfection; CCK8; Colony Formation Assay; Transwell Assay; Cell Cycle Assay; Western Blot; Bioinformatics Analysis; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); In Vivo Animal Model; H&E Staining; Survival Analysis; Cohort Study |
| Clinical significance: |
Circ_0027599 level was associated with overall survival of GC patients, and low circ_0027599 level indicated shorter overall survival time. |
| Description: |
Circ_0027599 is down-regulated in gastric cancer tissues and cells, and higher expression is associated with better overall survival. Functionally, circ_0027599 suppresses GC cell viability, colony formation, migration, invasion, cell cycle progression and xenograft tumour growth. Mechanistically, it sponges miR-21-5p to elevate RUNX1 expression, forming a circ_0027599/miR-21-5p/RUNX1 regulatory axis. |
| Confidence score: |
0.7794 |