circRNA basic information
circBase ID: hsa_circ_0084927
Name: hsa_circ_ESRP1
Synonym: -
Host Gene: ESRP1
Genomic location(hg19): chr8:95676924-95677424:+
Genomic location(hg38): chr8:94664696-94665196:+
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0002974
MONDO name: cervical cancer
Disease details: cervical cancer
Disease DO ID:
 4362
Disease MeSH ID:
 -
Disease NCIt ID:
 C9311
Disease ICD11 ID:
 1256072522
Disease OMIM ID:
 603956
Species: Human
Species details: Homo sapiens
Tissue specimen:

CSCC tissue; para-cancerous cervical tissues; normal cervical tissue
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: KLHL2, ATPBD4, LHX8, ZNF318
Associated microRNA: hsa-miR-520h, hsa-miR-874, hsa-miR-634, hsa-miR-1250, hsa-miR-520g
Biological function: promotes CSCC cell differentiation, proliferation, and metastasis
Molecular mechanism: Predicted ceRNA mechanism involving hsa-miR-520h and putative target genes (KLHL2; ATPBD4; LHX8; ZNF318)
Biological pathway or process:

ceRNA regulation (promotes); proliferation (promotes); metastasis (promotes)
Detected method:
Q
M
Validation methods:

Microarray; RT-qPCR; Bioinformatics Analysis; Clinical Sample Validation
Clinical significance:

potential diagnostic and therapeutic biomarkers
Description:

hsa_circ_0084927 is up-regulated in CSCC tissues and is proposed to function as a ceRNA by targeting miRNAs such as hsa-miR-520h, with downstream targets including KLHL2, ATPBD4, LHX8, and ZNF318. Its overexpression is associated with promoting CSCC cell differentiation, proliferation, and metastasis.
Confidence score:

0.4032
Other information
Title:

The profile analysis of circular RNAs in cervical cancer.

Journal: Medicine
Published: 2021
PubMed ID: 34596168
Study type:

combined biological and clinical study
Data availability: GSE102686
Code availability: -