| Expression pattern: |
UP |
| Associated gene: |
Wnt3a, beta-catenin, c-MYC, MMP2 |
| Associated microRNA: |
miR-665 |
| Biological function: |
Promotes CRC cell proliferation, migration, invasion, tumor growth, and distant metastasis. |
| Molecular mechanism: |
circLPP functions as a miR-665 sponge to relieve miR-665-mediated suppression of Wnt3a, thereby activating the Wnt3a/beta-catenin signaling pathway. |
| Biological pathway or process: |
Wnt/beta-catenin (promotes); proliferation (promotes); migration (promotes); invasion (promotes); metastasis (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
S
|
| Validation methods: |
Back-Splice Junction PCR / divergent primers PCR; RNase R Treatment; Sanger Sequencing; Actinomycin D / DRB Stability Assay; RT-qPCR; RNA-seq; FISH / smFISH; Clinical Sample Validation; Luciferase Reporter Assay; Transfection; CCK8; Colony Formation Assay; Transwell Assay; Wound Healing Assay; In Vivo Animal Model; H&E Staining; Western Blot; Survival Analysis; Bioinformatics Analysis |
| Clinical significance: |
High circLPP expression correlated with malignant progression, aggressive clinicopathological features, and poor prognosis in CRC patients; circLPP may serve as a diagnostic/prognostic biomarker and therapeutic target. |
| Description: |
circLPP/hsa_circ_0003759 is upregulated in colorectal cancer tissues and cell lines and is associated with aggressive clinicopathological characteristics and shorter overall survival. Functionally, it promotes CRC proliferation, migration, invasion, tumor growth, and metastasis. Mechanistically, circLPP acts as a miR-665 sponge to derepress Wnt3a and activate Wnt/beta-catenin signaling. |
| Confidence score: |
0.8459 |