| Expression pattern: |
UP |
| Associated gene: |
mRNAs |
| Associated microRNA: |
hsa-miR-6760-3p, hsa-miR-761, hsa-miR-6728-3p, hsa-miR-5693, hsa-miR-298, hsa-miR-367-5p |
| Biological function: |
unknown |
| Molecular mechanism: |
May function as a miRNA sponge by competitively binding hsa_miR-761 in a predicted circRNA/miRNA/gene network. |
| Biological pathway or process: |
ceRNA regulation (other); MAPK (other); thyroid hormone (other); Wnt/beta-catenin (other); EGFR (other) |
| Detected method: |
Q
M
|
| Validation methods: |
Microarray; RNase R Treatment; RT-qPCR; Clinical Sample Validation; Bioinformatics Analysis |
| Clinical significance: |
- |
| Description: |
hsa-circRNA_015115 is up-regulated in whole blood of T2DM patients with depression versus those without depression, supported by microarray and RT-qPCR. The study proposes a ceRNA/miRNA-sponge role, including competitive binding to hsa-miR-761 within a predicted circRNA/miRNA/mRNA network, potentially linking it to MAPK-related processes. |
| Confidence score: |
0.5135 |