circRNA basic information
circBase ID: hsa_circ_0003970
Name: hsa_circ_DOCK1
Synonym: -
Host Gene: DOCK1
Genomic location(hg19): chr10:128795011-128798571:+
Genomic location(hg38): chr10:126996747-127000307:+
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0008315
MONDO name: prostate cancer
Disease details: Prostate cancer
Disease DO ID:
 10283
Disease MeSH ID:
 D011471
Disease NCIt ID:
 C7378
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

PCa tissues; adjacent normal tissues
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-181b-2-3p, hsa-miR-196a-5p, hsa-miR-203b-3p, hsa-miR-211-5p, hsa-miR-497-3p, hsa-miR-548a-3p, hsa-miR-204-5p
Biological function: unknown
Molecular mechanism: predicted miRNA sponge (circRNA-miRNA-mRNA network)
Biological pathway or process:

MAPK (other); PI3K/AKT (other); lipid metabolism (other); cell cycle (other); p53 signaling (other); apoptosis (other)
Detected method:
Q
S
Validation methods:

RNA-seq; RT-qPCR; Clinical Sample Validation; Bioinformatics Analysis
Clinical significance:

Potential diagnostic metabolic biomarker for PCa
Description:

hsa_circ_0003970 is up-regulated in prostate cancer tissues and was validated by qRT-PCR. The work predicts it participates in a circRNA-miRNA-mRNA network and links it to PCa-related pathways (e.g., MAPK, PI3K/AKT, lipid-related processes), supporting its potential as a metabolic biomarker.
Confidence score:

0.4032
Other information
Title:

Five Circular RNAs in Metabolism Pathways Related to Prostate Cancer.

Journal: Frontiers in genetics
Published: 2021
PubMed ID: 33574834
Study type:

combined biological and clinical study
Data availability: PRJCA003890
Code availability: -