| Expression pattern: |
UP |
| Associated gene: |
KLF12 |
| Associated microRNA: |
miR-526b-3p |
| Biological function: |
promotes cisplatin resistance, proliferation, migration and invasion; inhibits apoptosis in CDDP-resistant CRC cells |
| Molecular mechanism: |
ceRNA sponge mechanism: circ_0071589 sponges miR-526b-3p to regulate KLF12 expression |
| Biological pathway or process: |
chemoresistance (inhibits); proliferation (promotes); apoptosis (inhibits); migration (promotes); invasion (promotes); ceRNA regulation (other) |
| Detected method: |
Q
|
| Validation methods: |
Back-Splice Junction PCR / divergent primers PCR; RNase R Treatment; RT-qPCR; Clinical Sample Validation; Bioinformatics Analysis; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); Transfection; CCK8; Cell Cycle Assay; Annexin V/PI Flow Cytometry; Transwell Assay; Western Blot; In Vivo Animal Model; IHC (Immunohistochemistry) |
| Clinical significance: |
Higher circ_0071589 expression in CDDP-resistant CRC tissues than in CDDP-sensitive tissues |
| Description: |
circ_0071589 is up-regulated in CDDP-resistant colorectal cancer tissues/cells and promotes cisplatin resistance and malignant behaviors. Mechanistically, it acts as a ceRNA sponge for miR-526b-3p to de-repress KLF12, thereby enhancing CDDP resistance; knockdown of circ_0071589 sensitizes CRC cells to cisplatin in vitro and in xenografts. |
| Confidence score: |
0.8298 |