| Expression pattern: |
UP |
| Associated gene: |
FOXM1 |
| Associated microRNA: |
miR-623 |
| Biological function: |
Promotes NSCLC cell viability, migration and invasion and inhibits apoptosis; supports xenograft tumor growth. |
| Molecular mechanism: |
Acts as a ceRNA that sponges miR-623 to regulate FOXM1 expression. |
| Biological pathway or process: |
proliferation (promotes); apoptosis (inhibits); migration (promotes); invasion (promotes); metastasis (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Survival Analysis; Bioinformatics Analysis; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); RNA Pull-Down; Transfection; CCK8; Annexin V/PI Flow Cytometry; Transwell Assay; Western Blot; In Vivo Animal Model |
| Clinical significance: |
High expression of circZNF609 indicated the lower overall survival; high expression of circZNF609 was an independent predictor of poor overall survival of NSCLC. |
| Description: |
circZNF609 is up-regulated in NSCLC and its high expression is associated with worse overall survival. Functionally, circZNF609 promotes NSCLC cell growth and metastatic behaviors and inhibits apoptosis, at least partly by sponging miR-623 to upregulate FOXM1; circZNF609 knockdown suppresses xenograft tumor growth. |
| Confidence score: |
0.7751 |