| Expression pattern: |
DN |
| Associated gene: |
726 mRNAs |
| Associated microRNA: |
hsa‐miR‐8055, hsa‐miR‐8063, hsa‐miR‐4494, hsa‐miR‐888‐3p, hsa‐miR‐6824‐5p |
| Biological function: |
inhibits proliferation, colony formation, migration and invasion; promotes apoptosis |
| Molecular mechanism: |
Predicted ceRNA mechanism via sponging miRNAs and regulating downstream mRNAs; implicated in PI3K-Akt signaling pathway |
| Biological pathway or process: |
proliferation (inhibits); apoptosis (promotes); migration (inhibits); invasion (inhibits); PI3K/AKT (other); ceRNA regulation (other) |
| Detected method: |
Q
S
|
| Validation methods: |
Back-Splice Junction PCR / divergent primers PCR; Sanger Sequencing; RT-qPCR; RNA-seq; RNase R Treatment; Transfection; MTT; Annexin V/PI Flow Cytometry; Transwell Assay; Colony Formation Assay; Bioinformatics Analysis; Clinical Sample Validation |
| Clinical significance: |
hsa_circ_0001360 may have potential as a biomarker for cSCC |
| Description: |
hsa_circ_0001360 is significantly down-regulated in cSCC tissues. Functionally, it acts as a tumor-suppressive circRNA in SCL-1 cells by inhibiting proliferation/colony formation, migration and invasion and by promoting apoptosis, with a predicted ceRNA network involving five miRNAs and many downstream mRNAs (potentially related to PI3K/AKT signaling). |
| Confidence score: |
0.7507 |