circRNA basic information
circBase ID: hsa_circ_0049271
Name: hsa_circ_KEAP1
Synonym: -
Host Gene: KEAP1
Genomic location(hg19): chr19:10610070-10610756:-
Genomic location(hg38): chr19:10499394-10500080:-
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005075
MONDO name: thyroid gland papillary carcinoma
Disease details: papillary thyroid carcinoma
Disease DO ID:
 3969
Disease MeSH ID:
 -
Disease NCIt ID:
 C4035
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

tumor tissue; normal thyroid tissue
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
DN
Associated gene: CLCNKB, FBXO27, FXYD6
Associated microRNA: hsa-miR-146b-3p
Biological function: May suppress expression of CLCNKB, FBXO27 and FXYD6 via miRNA sponging (as proposed in the ceRNA network).
Molecular mechanism: ceRNA mechanism (sponging hsa-miR-146b-3p) affecting CLCNKB/FBXO27/FXYD6.
Biological pathway or process:

ceRNA regulation (other)
Detected method:
M
Validation methods:

Microarray; RNA-seq; Bioinformatics Analysis; Survival Analysis
Clinical significance:

-
Description:

hsa_circ_0049271 is downregulated in PTC and included in the PFI-related ceRNA subnetwork. It is predicted to sponge hsa-miR-146b-3p and is associated in the network with regulation of CLCNKB, FBXO27, and FXYD6.
Confidence score:

0.4032
Other information
Title:

Progression Risk Assessment of Post-surgical Papillary Thyroid Carcinoma Based on Circular RNA-Associated Competing Endogenous RNA Mechanisms.

Journal: Frontiers in cell and developmental biology
Published: 2020
PubMed ID: 33553144
Study type:

bioinformatics study
Data availability: GSE93522; TCGA-THCA
Code availability: -