circRNA basic information
circBase ID: hsa_circ_0006988
Name: hsa_circ_LDLRAD3
Synonym: -
Host Gene: LDLRAD3
Genomic location(hg19): chr11:36248634-36248980:+
Genomic location(hg38): chr11:36227084-36227430:+
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0009831
MONDO name: malignant pancreatic neoplasm
Disease details: pancreatic cancer
Disease DO ID:
 1793
Disease MeSH ID:
 -
Disease NCIt ID:
 C9005
Disease ICD11 ID:
 542147910
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

pancreatic cancer tissues; adjacent non-tumorous tissues; plasma
Cell lines:

HPC-Y5; HPDE6-C7; Capan-2; Panc-1; SW1990; AsPC-1
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: CA19-9
Associated microRNA: -
Biological function: Potential biomarker indicative of tumor invasion capacity and metastatic potential in pancreatic cancer; associated with venous invasion, lymphatic invasion, and metastasis.
Molecular mechanism: -
Biological pathway or process:

metastasis (other); invasion (other)
Detected method:
Q
Validation methods:

RT-qPCR; Sanger Sequencing; divergent primers PCR; Back-Splice Junction PCR / divergent primers PCR; Clinical Sample Validation; ROC Analysis
Clinical significance:

circ-LDLRAD3 may be a biomarker in the diagnosis of pancreatic cancer; ROC AUC 0.67 alone and 0.87 combined with CA19-9.
Description:

circ-LDLRAD3 (hsa_circ_0006988) is up-regulated in pancreatic cancer tissues, plasma, and pancreatic cancer cell lines. It is associated with invasive/metastatic clinicopathological features and shows diagnostic utility, especially when combined with CA19-9.
Confidence score:

0.6291
Other information
Title:

Circular RNA circ-LDLRAD3 as a biomarker in diagnosis of pancreatic cancer.

Journal: World journal of gastroenterology
Published: 2017
PubMed ID: 29307994
Study type:

combined biological and clinical study
Data availability: GSE69362
Code availability: -