circRNA basic information
circBase ID: hsa_circ_0017444
Name: hsa_circ_WDR37
Synonym: cWDR37
Host Gene: Wdr37
Genomic location(hg19): chr10:1123846-1151207:+
Genomic location(hg38): chr10:1077906-1105267:+
Subcellular localization: extracellular
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005129
MONDO name: cataract
Disease details: cataract
Disease DO ID:
 83
Disease MeSH ID:
 D002386
Disease NCIt ID:
 C26713
Disease ICD11 ID:
 109841337
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

aqueous humor; AH samples
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: -
Associated microRNA: -
Biological function: cWDR37 is elevated in aqueous humor from glaucoma patients and can discriminate glaucoma patients from cataract patients.
Molecular mechanism: No molecular mechanism was tested for human cWDR37 in glaucoma; the study evaluated its diagnostic association in aqueous humor.
Biological pathway or process:

not specified
Detected method:
Q
Validation methods:

RT-qPCR; Clinical Sample Validation; ROC Analysis
Clinical significance:

cWDR37 level in aqueous humor could discriminate glaucoma patients from cataract patients, with specificity 86.67%, sensitivity 76.67%, and AUC 0.9367; monitoring cWdr37 levels could be used for the prognosis and diagnosis of glaucoma.
Description:

Human cWDR37/hsa_circ_0017444 is a homolog of mouse cWdr37 and is significantly increased in aqueous humor from glaucoma patients compared with cataract controls. Its aqueous humor level showed strong diagnostic performance for glaucoma, suggesting biomarker potential.
Confidence score:

0.4187
Other information
Title:

CircRNA expression profile and functional analysis in retinal ischemia-reperfusion injury.

Journal: Genomics
Published: 2021
PubMed ID: 33771636
Study type:

combined biological and clinical study
Data availability: https://doi. org/10.1016/j.ygeno.2021.03.026
Code availability: -