| Expression pattern: |
UP |
| Associated gene: |
- |
| Associated microRNA: |
hsa-miR-548b-3p |
| Biological function: |
potential microRNA sponging |
| Molecular mechanism: |
Negative co-expression with miRNA suggests sponging; binding sites predicted in circRNA sequence. |
| Biological pathway or process: |
ceRNA regulation (other) |
| Detected method: |
Q
S
|
| Validation methods: |
RNA-seq; Back-Splice Junction PCR / divergent primers PCR; Sanger Sequencing; RT-qPCR; Clinical Sample Validation; Bioinformatics Analysis |
| Clinical significance: |
diagnostic implications in breast cancer |
| Description: |
hsa_circ_0023990 is reported as up-regulated in early-stage breast cancer based on RNA-seq analysis and is suggested to interact with hsa-miR-548b-3p from co-expression and binding-site prediction. RT-qPCR was performed but did not show statistically significant up-regulation, so evidence strength is limited. |
| Confidence score: |
0.585 |