circRNA basic information
circBase ID: hsa_circ_0002111
Name: hsa_circ_PSD3
Synonym: -
Host Gene: PSD3
Genomic location(hg19): chr8:18622958-18662408:-
Genomic location(hg38): chr8:18765448-18804898:-
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005075
MONDO name: thyroid gland papillary carcinoma
Disease details: papillary thyroid cancer
Disease DO ID:
 3969
Disease MeSH ID:
 -
Disease NCIt ID:
 C4035
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

PTC tissue; adjacent normal tissue
Cell lines:

TPC-1; B-CPAP; Nthy-ori 3-1
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: -
Associated microRNA: -
Biological function: promotes PTC cell proliferation, migration and invasion
Molecular mechanism: Not explored in this study
Biological pathway or process:

proliferation (promotes); migration (promotes); invasion (promotes)
Detected method:
Q
M
Validation methods:

RT-qPCR; Microarray; Bioinformatics Analysis; Clinical Sample Validation; ROC Analysis; Transfection; CCK8; Colony Formation Assay; Transwell Assay; Wound Healing Assay
Clinical significance:

associated with advanced TNM stage and lymph-node metastasis; potential diagnostic tumor marker (AUC 0.833)
Description:

hsa_circ_0002111 is up-regulated in papillary thyroid cancer tissues and PTC cell lines. Functional knockdown experiments indicate it promotes PTC cell proliferation, migration, and invasion, and it shows potential diagnostic value (AUC 0.833), though its molecular mechanism was not investigated.
Confidence score:

0.6758
Other information
Title:

Increased Expression of hsa_circ_0002111 and Its Clinical Significance in Papillary Thyroid Cancer.

Journal: Frontiers in oncology
Published: 2021
PubMed ID: 33718243
Study type:

combined biological and clinical study
Data availability: GSE93522
Code availability: -