| Expression pattern: |
UP |
| Associated gene: |
GPRC5A |
| Associated microRNA: |
miR-1205, miR-382 |
| Biological function: |
promotes glioma cell proliferation, migration and invasion, inhibits apoptosis, and promotes tumor growth in vivo |
| Molecular mechanism: |
circ-UBAP2 acts as a sponge for miR-1205 and miR-382 to regulate GPRC5A expression (ceRNA-like mechanism) |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); apoptosis (inhibits) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; RNase R Treatment; Nuclear-Cytoplasmic Fractionation; Transfection; CCK8; Colony Formation Assay; Annexin V/PI Flow Cytometry; Transwell Assay; Wound Healing Assay; Western Blot; Luciferase Reporter Assay; In Vivo Animal Model; Bioinformatics Analysis; Clinical Sample Validation |
| Clinical significance: |
- |
| Description: |
circ-UBAP2 is up-regulated in glioma and promotes malignant phenotypes (proliferation, migration, invasion) while suppressing apoptosis. It functions mainly in the cytoplasm as a miRNA sponge for miR-1205 and miR-382, thereby relieving miRNA-mediated repression of GPRC5A and enhancing tumor growth in a cell line-derived xenograft model. |
| Confidence score: |
0.7421 |