| Expression pattern: |
UP |
| Associated gene: |
GPX4 |
| Associated microRNA: |
miR-193a-5p |
| Biological function: |
Promotes cervical cancer cell viability/proliferation and suppresses ferroptosis. |
| Molecular mechanism: |
circACAP2 acts as a ceRNA (miRNA sponge) for miR-193a-5p to upregulate GPX4, thereby repressing ferroptosis. |
| Biological pathway or process: |
ferroptosis (inhibits); proliferation (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Transfection; CCK8; Luciferase Reporter Assay; RNA Pull-Down Assay; Western Blot |
| Clinical significance: |
circACAP2 expression is upregulated in clinical cervical cancer samples and correlates negatively with miR-193a-5p and positively with GPX4. |
| Description: |
In cervical cancer cells and patient tumor tissues, circACAP2 is upregulated and functions as a ceRNA that sponges miR-193a-5p to increase GPX4 expression. Through the miR-193a-5p/GPX4 axis, circACAP2 promotes cell viability and suppresses ferroptosis-related phenotypes (lipid ROS and iron accumulation). |
| Confidence score: |
0.6672 |