circRNA basic information
circBase ID: hsa_circ_0001998
Name: -
Synonym: -
Host Gene: -
Genomic location(hg19): chr14:65922338-66028484:+
Genomic location(hg38): chr14:65455620-65561766:+
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005575
MONDO name: colorectal cancer
Disease details: colorectal cancer
Disease DO ID:
 5672, 9256
Disease MeSH ID:
 -
Disease NCIt ID:
 C4978
Disease ICD11 ID:
 -
Disease OMIM ID:
 114500
Species: Human
Species details: Homo sapiens
Tissue specimen:

CRC tissues; adjacent non-tumorous tissues / paired normal mucosa
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: TPM2
Associated microRNA: hsa-miR-424-5p
Biological function: potential roles in carcinogenesis as ceRNA for regulation of miRNA-mRNA network
Molecular mechanism: ceRNA mechanism via sponging hsa-miR-424-5p (bioinformatics-described)
Biological pathway or process:

ceRNA regulation (other)
Detected method:
S
Validation methods:

circRNA-seq; RNA-seq; Bioinformatics Analysis; Clinical Sample Validation
Clinical significance:

candidate diagnostic biomarkers or potential therapeutic targets (as a group of circRNAs)
Description:

hsa_circ_0001998 is one of the top up-regulated circRNAs used to build the CRC ceRNA network. The paper describes it (together with hsa_circ_0067163) as associated with sponging hsa-miR-424-5p and linking to TPM2 in the predicted regulatory network.
Confidence score:

0.4685
Other information
Title:

Identification and characterization of circRNAs as competing endogenous RNAs for miRNA-mRNA in colorectal cancer.

Journal: PeerJ
Published: 2019
PubMed ID: 31579577
Study type:

combined biological and clinical study
Data availability: PRJNA521856
Code availability: -