| Expression pattern: |
UP |
| Associated gene: |
IL-25 |
| Associated microRNA: |
miR-515-5p |
| Biological function: |
Enhances 5-Fu and cisplatin resistance in NPC cells; circNRIP1 knockdown increases sensitivity to 5-Fu and cisplatin. |
| Molecular mechanism: |
Acts as a ceRNA by sequestering miR-515-5p, relieving miR-515-5p-mediated suppression of IL-25 and thereby promoting chemoresistance. |
| Biological pathway or process: |
ceRNA regulation (promotes); drug resistance (promotes); NF-kappaB (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Luciferase Reporter Assay; Transfection; CCK8; ELISA; Clinical Sample Validation; Cohort Study; Survival Analysis; Bioinformatics Analysis |
| Clinical significance: |
High serum circNRIP1 is associated with chemoresistance and shorter overall survival; may be a diagnostic biomarker of chemoresistance in NPC. |
| Description: |
CircNRIP1 is up-regulated in the serum of chemoresistant NPC patients and in cisplatin-resistant NPC cell models. It promotes 5-Fu and cisplatin resistance by sponging miR-515-5p to derepress IL-25, and high serum circNRIP1 is associated with worse overall survival. |
| Confidence score: |
0.7283 |