| Expression pattern: |
UP |
| Associated gene: |
SLC7A11, GPX4, Ago2 |
| Associated microRNA: |
miR-375, miR-409-3P, miR-515-5p |
| Biological function: |
Promotes cervical cancer cell proliferation and tumor growth; inhibits ferroptosis. |
| Molecular mechanism: |
Acts as a ceRNA/miRNA sponge for miR-375, miR-409-3P and miR-515-5p to regulate SLC7A11 and ferroptosis-related redox balance (GSH/GSSG, lipid peroxidation, GPX4). |
| Biological pathway or process: |
proliferation (promotes); ferroptosis (inhibits); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Nuclear-Cytoplasmic Fractionation; Transfection; CCK8; BrdU; RIP (RNA Immunoprecipitation); Luciferase Reporter Assay; Western Blot; In Vivo Animal Model; IHC (Immunohistochemistry) |
| Clinical significance: |
circEPSTI1 might act as a new and useful biomarker for monitoring and treatment target for cervical cancer. |
| Description: |
circEPSTI1 is up-regulated in cervical cancer cell lines and promotes proliferation and xenograft tumor growth. Mechanistically, it acts as a ceRNA that sponges miR-375/miR-409-3P/miR-515-5p to increase SLC7A11, thereby inhibiting ferroptosis (reduced lipid peroxidation and maintained GSH/GPX4). It is proposed as a potential biomarker and therapeutic target in cervical cancer. |
| Confidence score: |
0.7081 |