circRNA basic information
circBase ID: hsa_circ_0047322
Name: -
Synonym: -
Host Gene: -
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0004986
MONDO name: urinary bladder carcinoma
Disease details: bladder cancer
Disease DO ID:
 4007
Disease MeSH ID:
 -
Disease NCIt ID:
 C4912
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

BCa tissue; adjacent normal tissue; normal bladder tissues
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: CENPA, HIST1H2BJ, HIST1H2BO, HIST1H3H, HIST1H3B, HIST1H3F
Associated microRNA: miR-616, miR-515-5p, miR-647, miR-1178, hsa-miR-515-5p
Biological function: May act as a miRNA sponge (ceRNA) to regulate mRNA expression in bladder cancer.
Molecular mechanism: ceRNA (miRNA sponge) mechanism predicted; multiple circRNA-miRNA-hub gene regulatory axes involving hsa-miR-515-5p and hub genes.
Biological pathway or process:

ceRNA regulation (other)
Detected method:
M
Validation methods:

Microarray; Bioinformatics Analysis
Clinical significance:

-
Description:

In bladder cancer, has_circ_0047322 was identified as an up-regulated circRNA from microarray analysis. The study predicts a ceRNA role for has_circ_0047322, particularly via binding hsa-miR-515-5p and linking to hub genes such as CENPA and multiple HIST1H* genes within a circRNA-miRNA-mRNA network.
Confidence score:

0.1768
Other information
Title:

Identification of a potentially functional circRNA-miRNA-mRNA ceRNA regulatory network in bladder cancer by analysis of microarray data.

Journal: Translational andrology and urology
Published: 2021
PubMed ID: 33532293
Study type:

bioinformatics study
Data availability: GSE92675; TCGA
Code availability: -