circRNA basic information
circBase ID: -
Name: hsa_circ_NRIP1
Synonym: circ-NRIP1
Host Gene: NRIP1
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0001056
MONDO name: gastric cancer
Disease details: Gastric cancer
Disease DO ID:
 10534
Disease MeSH ID:
 -
Disease NCIt ID:
 C9331
Disease ICD11 ID:
 1397617262
Disease OMIM ID:
 613659
Species: Human
Species details: Homo sapiens
Tissue specimen:

GC tissues; adjacent normal samples; excised tumor tissues
Cell lines:

GES-1; HGC-27; AGS
In vivo animal model:

cell line-derived xenograft
circRNA-disease information
Expression pattern:
UP
Associated gene: MYH9, HK2, PKM2
Associated microRNA: miR-186-5p
Biological function: promotes cell proliferation, migration, glycolysis and tumor growth; inhibits apoptosis in gastric cancer
Molecular mechanism: circ-NRIP1 acts as a ceRNA by sponging miR-186-5p, thereby derepressing MYH9 and promoting glycolysis-related proteins (HK2, PKM2) and GC progression
Biological pathway or process:

glycolysis (promotes); proliferation (promotes); migration (promotes); apoptosis (inhibits); ceRNA regulation (promotes)
Detected method:
Q
Validation methods:

RT-qPCR; Transfection; MTT; Annexin V/PI Flow Cytometry; Transwell Assay; Western Blot; Luciferase Reporter Assay; Bioinformatics Analysis; Clinical Sample Validation; In Vivo Animal Model
Clinical significance:

circ-NRIP1 was suggested as a promising biomarker for the treatment of GC
Description:

In gastric cancer, circ-NRIP1 is up-regulated and promotes proliferation, migration, glycolysis and tumor growth while suppressing apoptosis. Mechanistically, circ-NRIP1 sponges miR-186-5p to increase MYH9 expression, which contributes to glycolytic activation (e.g., HK2/PKM2) and tumor progression.
Confidence score:

0.6536
Other information
Title:

circ-NRIP1 Promotes Glycolysis and Tumor Progression by Regulating miR-186-5p/MYH9 Axis in Gastric Cancer.

Journal: Cancer management and research
Published: 2020
PubMed ID: 32765095
Study type:

combined biological and clinical study
Data availability: -
Code availability: -