circRNA basic information
circBase ID: hsa_circ_0059354
Name: hsa_circ_RASSF2
Synonym: circRASSF2
Host Gene: RASSF2
Genomic location(hg19): chr20:4760668-4766974:-
Genomic location(hg38): chr20:4780022-4786328:-
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0007254
MONDO name: breast cancer
Disease details: breast cancer
Disease DO ID:
 1612
Disease MeSH ID:
 -
Disease NCIt ID:
 C9335
Disease ICD11 ID:
 1047754165
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

BC tissues; matched noncancerous normal tissues; serum
Cell lines:

T47D; MCF-7; BT549; Hs-578 T; MDA-MB-231; MDA-MB-468; MCF-10A; MCF7
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: HOXA1
Associated microRNA: miR-1205 / miRNA-1205
Biological function: Promotes breast cancer cell proliferation, colony formation, migration and invasion; inhibits apoptosis.
Molecular mechanism: Acts as a miR-1205 sponge to relieve repression of HOXA1, increasing HOXA1 protein and promoting breast cancer progression.
Biological pathway or process:

ceRNA regulation (promotes); proliferation (promotes); migration (promotes); invasion (promotes); apoptosis (inhibits)
Detected method:
Q
Validation methods:

RT-qPCR; Clinical Sample Validation; Survival Analysis; ROC Analysis; Bioinformatics Analysis; Luciferase Reporter Assay; Transfection; CCK8; Colony Formation Assay; Annexin V/PI Flow Cytometry; Western Blot; Transwell Assay
Clinical significance:

circRASSF2 is increased in BC tissues and serum; high circRASSF2 correlates with metastasis and advanced clinicopathological features; high expression predicts shorter OS and PFS; serum circRASSF2 shows diagnostic value (ROC AUC 0.9323).
Description:

circRASSF2 is up-regulated in breast cancer tissues and patient serum and is associated with metastasis, advanced clinicopathologic features, and poor OS/PFS. Functionally, circRASSF2 promotes proliferation, colony formation, migration, and invasion and suppresses apoptosis in BC cells. Mechanistically, it acts as a ceRNA that sponges miR-1205 to increase HOXA1 expression (circRASSF2/miR-1205/HOXA1 axis).
Confidence score:

0.7408
Other information
Title:

CircRASSF2 acts as a prognostic factor and promotes breast cancer progression by modulating miR-1205/HOXA1 axis.

Journal: Bioengineered
Published: 2021
PubMed ID: 34180753
Study type:

combined biological and clinical study
Data availability: -
Code availability: -