| Expression pattern: |
UP |
| Associated gene: |
RHOC, STAT3 |
| Associated microRNA: |
miR-17-5p |
| Biological function: |
promotes proliferation, migration and invasion; promotes tumor growth in vivo |
| Molecular mechanism: |
ceRNA mechanism: circAKT3 sponges miR-17-5p to relieve repression of RHOC and STAT3 |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); apoptosis (other); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; RNase R Treatment; Luciferase Reporter Assay; Transfection; CCK8; Wound Healing Assay; Transwell Assay; Western Blot; In Vivo Animal Model; Clinical Sample Validation |
| Clinical significance: |
tumor size, lymphatic metastasis, and TNM staging were positively related to the upregulation of circAKT3 in the tissue samples |
| Description: |
circAKT3 is up-regulated in esophageal cancer tissues and cell lines and promotes malignant behaviors (proliferation, migration, invasion) and xenograft tumor growth. Mechanistically, circAKT3 functions as a ceRNA by sponging miR-17-5p, thereby increasing RHOC and STAT3 expression. |
| Confidence score: |
0.6966 |