circRNA basic information
circBase ID: hsa_circ_0049783
Name: hsa_circ_CLEC17A
Synonym: -
Host Gene: CLEC17A
Genomic location(hg19): chr19:14705328-14705612:+
Genomic location(hg38): chr19:14594516-14594800:+
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0007256
MONDO name: hepatocellular carcinoma
Disease details: hepatocellular carcinoma
Disease DO ID:
 684, 686
Disease MeSH ID:
 D006528
Disease NCIt ID:
 C3099
Disease ICD11 ID:
 1294035808
Disease OMIM ID:
 114550
Species: Human
Species details: Homo sapiens
Tissue specimen:

tumor tissue; plasma
Cell lines:

HepG2; Huh7; Hep3B
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: ZWINT
Associated microRNA: hsa-miR-18a-3p
Biological function: unknown
Molecular mechanism: Putative miRNA sponge (ceRNA) interacting with hsa-miR-18a-3p and linked to ZWINT within a circRNA-miRNA-mRNA network.
Biological pathway or process:

cell cycle (other); DNA replication (other); ceRNA regulation (other)
Detected method:
M
Validation methods:

Microarray; Clinical Sample Validation; Bioinformatics Analysis
Clinical significance:

Potential biomarker in tissue and plasma for HCC (up-regulated in both).
Description:

hsa_circ_0049783 is up-regulated in HCC tissue and plasma based on circRNA microarray meta-analysis. The study proposes a ceRNA module hsa_circ_0049783/hsa-miR-18a-3p/ZWINT within a circRNA-miRNA-mRNA regulatory network, but without experimental circularity/RT-qPCR validation for this circRNA.
Confidence score:

0.348
Other information
Title:

Three novel circRNAs upregulated in tissue and plasma from hepatocellular carcinoma patients and their regulatory network.

Journal: Cancer cell international
Published: 2021
PubMed ID: 33482819
Study type:

bioinformatics study
Data availability: GSE78520; GSE94508; GSE97332; GSE135806; GSE76903; GSE14520; TCGA-LIHC
Code availability: -