| Expression pattern: |
DN |
| Associated gene: |
- |
| Associated microRNA: |
hsa-miR-20a-5p, hsa-miR-93-5p, hsa-miR-106b-5p |
| Biological function: |
impedes CC cell proliferation, migration, and invasion; tumor-suppressing activity in cervical cancer |
| Molecular mechanism: |
ceRNA (miRNA sponge): hsa_circ_0107593 directly sponges hsa-miR-20a-5p/93-5p/106b-5p and suppresses their tumor-promoting effects |
| Biological pathway or process: |
proliferation (inhibits); migration (inhibits); invasion (inhibits); ceRNA regulation (other); AMPK (other); lipid metabolism (other) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Transfection; CCK8; Colony Formation Assay; Wound Healing Assay; Transwell Assay; Luciferase Reporter Assay; ROC Analysis; Bioinformatics Analysis |
| Clinical significance: |
Could serve as a diagnostic biomarker; low expression correlated with tumor diameter, FIGO stage, and myometrial invasion |
| Description: |
hsa_circ_0107593 is down-regulated in cervical cancer tissues and cell lines and functions as a tumor suppressor by inhibiting proliferation, migration, and invasion. Mechanistically, it sponges hsa-miR-20a-5p, hsa-miR-93-5p, and hsa-miR-106b-5p, and shows diagnostic potential by ROC analysis. |
| Confidence score: |
0.7113 |