| Expression pattern: |
UP |
| Associated gene: |
CCND1, AGO2 |
| Associated microRNA: |
miR-142-5p |
| Biological function: |
Promotes NSCLC cell proliferation, colony formation, migration, tumorigenicity and metastasis, while inhibiting apoptosis; silencing circSYNJ1 causes cell cycle arrest in the G2 phase. |
| Molecular mechanism: |
circSYNJ1 acts as a competing endogenous RNA that sponges miR-142-5p to regulate CCND1 expression. |
| Biological pathway or process: |
ceRNA regulation (promotes); proliferation (promotes); migration (promotes); metastasis (promotes); apoptosis (inhibits); cell cycle (promotes) |
| Detected method: |
Q
S
|
| Validation methods: |
RT-qPCR; RNase R Treatment; circRNA-seq; Clinical Sample Validation; Nuclear-Cytoplasmic Fractionation; Bioinformatics Analysis; Survival Analysis; Transfection; CCK8; Colony Formation Assay; Annexin V/PI Flow Cytometry; Cell Cycle Assay; Transwell Assay; Luciferase Reporter Assay; RNA Pull-Down; RIP (RNA Immunoprecipitation); Western Blot; In Vivo Animal Model |
| Clinical significance: |
Higher circSYNJ1 expression is correlated with poor prognosis, advanced staging, metastasis, and reduced survival; circSYNJ1 is proposed as a potential diagnostic and prognostic biomarker for NSCLC. |
| Description: |
circSYNJ1/circSNYJ1 is up-regulated in NSCLC tissues and cell lines and high expression is associated with poor prognosis. It promotes NSCLC proliferation, colony formation, migration, tumorigenicity and metastasis while suppressing apoptosis, mainly through a ceRNA mechanism in which it sponges miR-142-5p to regulate CCND1. |
| Confidence score: |
0.8571 |