| Expression pattern: |
UP |
| Associated gene: |
QKI |
| Associated microRNA: |
- |
| Biological function: |
potential biomarker for pathological status indication of heart disease |
| Molecular mechanism: |
host gene-associated increase (positive correlation with linear transcript); QKI-dependent circRNA biogenesis |
| Biological pathway or process: |
not specified |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation |
| Clinical significance: |
circSLC8A1 expression was significantly increased in heart tissues from patients suffering from dilated cardiomyopathy, compared with healthy controls, suggesting it may indicate pathological status of heart disease. |
| Description: |
circSLC8A1 is significantly up-regulated in dilated cardiomyopathy heart tissue versus healthy controls by qRT-PCR. Its increase correlates with increased SLC8A1 linear transcripts and is sensitive to QKI knockdown in hiPSC-derived cardiomyocytes, supporting a QKI-linked biogenesis/maintenance. The study proposes circSLC8A1 as a potential biomarker indicating pathological status of heart disease. |
| Confidence score: |
0.2995 |