circRNA basic information
circBase ID: hsa_circ_0133622
Name: hsa_circ_DGKB
Synonym: -
Host Gene: hsa-miR-873
 
 
 
Disease basic information
DO ID:
 769
DO name: neuroblastoma
Disease details: neuroblastoma
Species: human
Species details: human
Sample type: cell line
Sample type details: NB cell lines (SK-N-SH, SH-SY5Y)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: GLI1
Associated microRNA: hsa-miR-873
Biological function: promoted the proliferation, migration, invasion, and tumorigenesis of NB cells and reduced cell apoptosis, and vice versa
Molecular mechanism: targeting hsa-miR-873/GLI1 axis
Survival: -
Supported No.:
 1
Description:

our work proved that circDGKB promoted NB progression via targeting miR-873/GLI1 axis in vitro and in vivo. Our study provided a new target for NB treatment and indicated that circDGKB could act as a novel diagnostic marker for NB.
Other information
Title:

Circular RNA DGKB Promotes the Progression of Neuroblastoma by Targeting miR-873/GLI1 Axis.

Journal: Front Oncol
Published: 2020/8/15
PubMed ID: 32793474