circRNA basic information
circBase ID: hsa_circ_0008197
Name: -
Synonym: -
Host Gene: -
Genomic location(hg19): chr1:51032748-51061888:-
Genomic location(hg38): chr1:50567076-50596216:-
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0001056
MONDO name: gastric cancer
Disease details: gastric cancer
Disease DO ID:
 10534
Disease MeSH ID:
 -
Disease NCIt ID:
 C9331
Disease ICD11 ID:
 1397617262
Disease OMIM ID:
 613659
Species: Human
Species details: Homo sapiens
Tissue specimen:

gastric cancer tissues; adjacent normal tissues
Cell lines:

AGS; HGC-27
In vivo animal model:

-
circRNA-disease information
Expression pattern:
DN
Associated gene: PGC, SNHG16
Associated microRNA: hsa-mir-98-5p, hsa-let-7f-5p, hsa-let-7c-5p
Biological function: hsa_circ_0008197 is downregulated in gastric cancer tissues, positively correlated with PGC expression, and co-mediates a PGC-related ceRNA network that may influence gastric cancer progression at the post-transcriptional level.
Molecular mechanism: ceRNA mechanism involving the SNHG16/hsa_circ_0008197-mir-98-5p/hsa-let-7f-5p/hsa-let-7c-5p-PGC axis
Biological pathway or process:

ceRNA regulation (other)
Detected method:
Q
S
Validation methods:

RNase R Treatment; circRNA-seq; RT-qPCR; Clinical Sample Validation; Bioinformatics Analysis; Transfection
Clinical significance:

-
Description:

hsa_circ_0008197 was identified as a PGC expression-related circRNA in gastric cancer and was validated by qRT-PCR as downregulated in gastric cancer tissues. The study proposes that hsa_circ_0008197, together with SNHG16, participates in a ceRNA axis involving hsa-mir-98-5p, hsa-let-7f-5p, hsa-let-7c-5p, and PGC, potentially modulating PGC expression and gastric cancer progression.
Confidence score:

0.62
Other information
Title:

Pepsinogen C expression-related lncRNA/circRNA/mRNA profile and its co-mediated ceRNA network in gastric cancer.

Journal: Functional & integrative genomics
Published: 2021
PubMed ID: 34463892
Study type:

combined biological and clinical study
Data availability: GSE164166; The data that support the results of this manuscript are available from the corresponding author upon reasonable request.
Code availability: -